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Massive Process Cost Savings.
No Flash/SFC/HPLC Phase to purchase.
No replacement solvent to purchase.
Appropriate solvent choice, allows very
low cost recycling of your CPC solvents.
After instrument purchase, your main
running cost will only be Electricity.
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Laboratory Scale Quattro CPC & CCC Prices
Quattro QuikPrep™ / LabPrep™ CPC & CCC units: 250 to 2000ml total instrument volumes. Options of multiple volumes per instrument from 30ml. Price range £27,500 to £87,500.
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Scaling-Up Your Application?
Scale-up to multiple 10’s tonnes per annum possible. For multiple 100’s tonnes per annum, please phone or email
Pilot & Process Scale Quattro CPC Prices
4.8 litres Quattro PilotPrep™ CPC £136,000
CANNABINOID & OTHER INDUSTRIES REQUIRING PROCESS CHROMATOGRAPHY FOR MULTIPLE TONNES PER ANNUM, SPECIAL OFFER UNTIL AUGUST 2023
1 x 12 litres Quattro ProcessPrep™ CPC £187,000
2 x 12 litres Quattro ProcessPrep™ CPC £340,000
4 x 12 litres Quattro ProcessPrep™ CPC £625,500
1 x 50 litres Quattro ProcessPrep™ CPC £650,000
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To the above pricing for scale-up, must be added customised Ancillary Instrumentation:- Pumps, Detector, Fraction Collection, Control Computer Etc., to match your needs and budget. Or provide your own existing or new ancillary instrumentation.
We manufacture both Hydrodynamic CCC (Planetary CCC, HSCCC, HPCCC, HPL-LC™) and Hydrostatic CCC (Droplet Centrifugal Partition Chromatography, CPC, HPCPC) at scales from 30 ml to 100+ litres. We have units in both research laboratories and process manufacture units throughout the World. We collaborate with Research Institutes / Universities, for both standard solvents and IONIC LIQUID BIPHASIC CCC/CPC EXTRACTION & CHROMATOGRAPHY RESEARCH PROGRAMME
We can custom build both CCC & CPC unit’s specific for your requirements because of our unique modular construction. Options of different CCC bore or CPC cell / chamber sizes, different volumes on the same instrument. We can custom design to accommodate your specific needs, within your budget. Other competitors cannot match our design and build flexibility. Just ask them and us to custom build to your specific needs and budget. We will custom build to match your requirements.
Unique 2D Spiral CCC for UK client Unique Dual Flow for USA client AECS Exhibiting at CCC 2014
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PREPARATIVE CHROMATOGRAPHY. CENTRIFUGAL PARTITION & COUNTER CURRENT CHROMATOGRAPHY
Mass Scales:- Laboratory Scale of Milligrams, up to Industrial Scale of Tonnes Per Annum
• Ideal HPLC-MS pre-prep; no column induced degradation or adsorption
• Uniquely allows infinitely polar to infinitely non-polar prep in one run
• Contract laboratory and process method development services available
• Easily scale-up from micro-gram to your tonne plus process chromatography scale
• Orthogonal selectivity options compared to process chromatography by HPLC/Flash/SFC
• No solubility problems; massive range of solvents available
• IL / SFC / SFC-MS / MS / MS-MS / HPLC / HPLC-MS compatible
• High process chromatography mass loading (typically 5 to 40 g per 1 litre capacity)
• Inject up to 10+ % coil volume without excessive band spreading
• High pressure (1000psi+) + high “G” (80-150)(250)(350+) options
• Only manufacturers of both hydrodynamic & hydrostatic CCC
• New dedicated IONIC LIQUID CHROMATOGRAPHY/EXTRACTION CCC/CPC
• New MULTI-COIL, 2D & 3D DUAL-FLOW CCC/CPC extraction options,
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Click this link to read our review of Ionic Liquid-Counter Current Chromotography / Centrifugal Partition Chromotograhy {IL-CCC/IL-CPC} Research in Topics in Current Chemistry. MEDICINAL CANNABINOIDS, PROTEINS, API’s, ETC : |
WHY YOU NEED QUATTRO CCC / QUATTRO CPC INSTRUMENTS?
LabPrep™ Total volume options from 250ml to 2000ml. Options of 2, 3 or 4 coils per instrument. You can choose multiple volume of coils to suit your specific needs. Coils of same id can be utilised in series, to gain resolution or additional mass injected. Coil id options: 1 mm id, 2 mm id, 4.6 mm id. Coil material options: PTFE, PFA, PEEK, Stainless Steel.
QuikPrep™ & LabPrep™ up to ~2000ml, price depending number coils, coil 1d / volume
PilotPrep™ 4.8 litres CCC. Can work in standard laboratory.
Images of Counter Current Chromatograph and Centrifugal Partition Chromatograph, showing CCC & CPC plus ancillaries at AECS-QuikPrep Ltd Demonstration Laboratory
Note: The Quattro PilotPrep CPC shown can process kilos per day, but still be utilised in a standard laboratory.
The applications on the left side boxes and given in the various slide shows on right side, represent a fraction od AECS's research experience in CCC & CPC.
AECS-QuikPrep Ltd has been conducting fundamental liquid-liquid chromatography research since 1993. We have innovated many important liquid-liquid chromatography instrument designs. Others have copied, but never bettered our designs, or vaguely approach the safety features of our instrumentation. Most our research has been for confidential research projects, in the main for Pharmaceutical and Agrochemical Companies. Studies for both synthetic and natural products. We have also co-researched with several major International Government Research Laboratories, plus Universities Worldwide .
Please note our experience dates from 1993 in liquid-liquid chromatography instrument design, manufacture and research. This compares very favourably to many of our present competitor CCC and CPC companies, some of which never even existed in their present form a few years ago. Some are very recent Venture Capital funded start-ups. Others are run by companies that recently purchased failed CPC French competitors. Some competitors sell purified target compound products, that are the equivalent to their clients own products. AECS-QuikPrep Ltd. never does this. Therefore if you need a laboratory, or tonne plus, per annum process method, then come to the experts, AECS-QuikPrep Ltd. No other company comes close to AECS-QuikPrep Ltd's experience in method development, or guarantees never to compete with you on target compound sales.
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Novel & New: Sun rotors can be custom made in Stainless Steel or Titanium (for proteins etc).
Instruments
can have, 1 or 2 different id cell (chamber) bores, with pressure
abilities of 1000+ psi, with typically “on-column” loadings of 5 to 40
g per 1 litre. HPCPC is ideal for MAB’s, proteins, peptides &
enzymes, other organic and inorganic extractions or chromatography
purifications.
AECS’s unique multi-block CPC rotor design offers specification options and tolerance to client induced mistakes causing CPC rotor blockage etc., which means significantly less downtime than any competitor. All Quattro CPC built to ISO 9001.
QuikPrep™ & LabPrep CPC™ Laboratory
~250 ml to 2000 ml, Stainless Steel rotor.
PilotPrep™ 4.8 litres. May be used in standard laboratories worldwide.
ProcessPrep™ any volume up to 100's of litres. Must be used in Intrinsically Safe \ Explosion Proof ATEX 1, in Europe
or C1-D1 in the USA or Canada.
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Centrifugal Partition Chromatography Medicinal Cannabinoid Chromatographs performed on our clients’ samples…...
Modular design, and the use of interchangeable components is common in aerospace, car, electronics etc industry. But only AECS-QuikPrep has employed this concept to countercurrent chromatography. We did to ensure success in scale-up..
The AECS brings you both talent and stability. AECS has been trading as same family-owned Company for approximately 38 years. Since 1983 AECS has been doing contract design research for third party instrument companies. Projects included the design of moving belt HPLC-MS, HPLC-FID and HPLC-MPD detectors; evaporative light scatter detectors; the world's first peltier HPLC column air ovens / chillers, etc. AECS has also helped an USA based HPLC Column Company create completely new HPLC column / phase product lines. AECS has built numerous prototype instruments for Blue-Chip International Companies.
AECS built our first Quattro CCC™ in the early 1990's, when Smith Kline Beecham were not prepared to purchase the then existing CCC / CPC instrumentation, and placed an open-design Purchase Order with AECS for what became the Quattro CCC™ Mk I. They like many others, before and since, trusted AECS's design expertise, and contracted AECS to build an improved design with regard to both safety and performance. Since then we have designed and built numerous custom Quattro HPL-LC™ for many clients. We offer our client’s proven, but ever evolving, commercially relevant CCC / CPC units. We have over 28 years of worldwide LLC commercial trading experience.
Please consider requesting Dr Leslie Brown visiting you to discuss your larger scale process needs.
IMAGES OF QUATTRO CENTRIFUGAL PARTITION CHROMATOGRAPHS FOR PROCESS CHROMATOGRAPHY OF MEDICINAL CANNABINOIDS ETC
First Delivery Equipment PilotPrep USA Early Stage Install PilotPrep USA.
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Installation with on-site training in your laboratory for one week included in Retail Price for Quattro PiliotPrep™ and ProcessPrep™, is optional at additional cost, for time and expenses, plus allowing for travel restriction.
The modular Process Compatible, ATEX 1 specification in Europe, C1-D1 specification in USA and Canada, Quattro ProcessPrep HPCPC start at 12 litres and go to 100's of litres.
Or consider our Process HPCPC for Simulated Moving Bed use, standard solvent or IONIC LIQUID solvents or Liquid CO2 use for CHROMATOGRAPHY OR EFFICIENT EXTRACTION.
Dr Les Brown has extensive commercial experience in laboratory and process HPCCC, HPL-LC™, plus CPC and HPCPC. He has scale-up experience from laboratory to the process Quattro HPCPC™ etc., which will stand you in a highly favoured position, when you move to potentially multiple tonnes per annum GMP production. The Quattro CCC™ / HPL-LC™ / CPC™ & HPCPC™ are respected quality products, with clients throughout the World. Our unique high backpressure capability will facilitate HPLC-MS, SFE, SFC, SFC-MS, Ionic Liquid research / process production by either efficient extraction or chromatography in laboratory + process procedures.
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on left for "INTRODUCTION" slide show scientific presentation