PHONE : UK +44 (0) 783 876 1524
Direct Mobile for Dr Leslie Brown, for you personal service
GUIDE PRICING TO ASSIST YOUR BUDGETING.
Quattro CCC & CPC units: 140 to 2000mls, price range £16,500 to £55,000
Scaling-Up your application?
Scale-up to multiple tonnes per annum possible.
If your CCC or CPC budget below UK POUNDS:
100,000 Consider PilotPrep, Non-Atex 2 to 4.5 Litre, CCC, or CPC (Ti or S/S rotor) 140,000 Consider multiple PilotPreps, Non-Atex 2 to 4.5 Litre, CCC or CPC
Or consider Atex rated ProcessPrep 6+ Litre CPC (Ti or S/S rotor) 300,000 Consider multiple PilotPreps, Non-Atex 2 to 4.5 L, CCC or CPC
Or consider multiple Atex rated ProcessPreps 6+ Litre CPC
LIMITED PERIOD ONLY, OPTION 40 LITRE PARTITRON CPC FOR SAME PRICE AS 25 LITRE BELOW.
500,000 Consider 25 Litre Partitron CPC 1,000,000 Consider 2 x 25 Litre Partitron CPC 1,500,000+ Consider custom made Partitron CPC to your maximum volume
The above pricing for scale-up, could include customised Ancillary
Instrumentation to match your needs and budget. We have considerable
specification flexibility, and always match our quotes to give you the
best value, to as closely match your needs as possible, for your budget.
& Couturier are undoubtedly the World Leaders in Counter-Current,
Centrifugal Partition, Liquid-Liquid, Ionic Liquid Chromatography /
We manufacture both Hydrodynamic CCC
(Planetary CCC, HSCCC, HPCCC, HPL-LC™) and Hydrostatic CCC (Droplet
Centrifugal Partition Chromatography, CPC, HPCPC) at scales from 30 ml
to 100+ litres. We have units in both research laboratories and process
manufacture units throughout the World. We collaborate with Research
Institutes / Universities, for both standard solvents and IONIC LIQUID
BIPHASIC CCC/CPC EXTRACTION & CHROMATOGRAPHY RESEARCH PROGRAMMES.
We can carry out both Contract Preparation and Method Development /
Feasibility Studies. Why not contact us to discuss your Laboratory and
/ or Process needs? Feasibility Studies from £2000/week.
We can custom build both CCC & CPC unit’s specific for your
requirements because of our unique modular construction. Options of
different CCC bore or CPC cell / chamber sizes, different volumes on
the same instrument. We can custom design to accommodate your specific
needs, within your budget. Other competitors cannot match our design
and build flexibility. Just ask them and us to custom build to your
specific needs and budget. We will custom build to match your
requirements. It is most likely our competitors will not custom build,
and will instead try to sell an existing model that does not exactly
match your needs or budget.
Totally committed to helping our
countercurrent / Ionic Liquids, Liquid CO2, SFE, SFC, chromatography /
extraction clients understand and benefit from HPCCC / HPCPC / HPL-LC™.
COUNTER CURRENT & CENTRIFUGAL PARTITION CHROMATOGRAPHY, PLUS HPLC, IL-LC AND SFC
Together AECS-QuikPrep (UK) and Couturier (France) bring you CCC / CPC preparative chromatography / extraction products at scales from micro-gram to process scale.
• Save ~90% process chromatography/extraction, solvent/column costs
• Ideal HPLC-MS pre-prep; no column induced degradation or adsorption
• Uniquely allows infinitely polar to infinitely non-polar prep in one run
• Contract preparative & extraction services available
• Easily scale-up from micro-gram to your tonne plus process scale
• Orthogonal selectivity options compared to HPLC / Flash / SFC
• No solubility problems; massive range of solvents available
• IL / SFC / SFC-MS / MS / MS-MS / HPLC / HPLC-MS compatible
• High mass loading (typically 5 to 40 g per 1000ml capacity)
• Inject up to 10+ % coil volume without excessive band spreading
• High pressure (1000psi+) + high “G” (80-150)(250)(350+) options
• Only manufacturers of both hydrodynamic & hydrostatic CCC
• New dedicated IONIC LIQUID CHROMATOGRAPHY/EXTRACTION CCC/CPC
• New MULTI-COIL, 2D & 3D DUAL-FLOW CCC/CPC extraction options,
Quattro HPL-LC™ / HTPrep™ Video (2 bobbins, 4 coils / 3 coil id’s). Door safety
mechanism disabled for this demonstration video.Set spin speeds are very constant. The video
judder is caused by camera/internet
Direct link to our publication on use of high percentage Ionic
Liquids in Counter Current Chromatography, click on picture.
New Book Chapters / Patents & Publications to follow.
Why HPLC users etc need our Quattro / Partitron HPCCC & HPCPC products...
Novel & New: Coils can
be custom made in PTFE, PFA, PEEK, Stainless Steel (S/S) or Titanium.
“G” Force can be Standard (S)(80 to 150G), High (H)(250G+)or unique to us, our new Ultra (U) (350G+), (UPCCC™) / (UPL-LC™).
Your Instrument could have coils with, 1, 2, 3 or even 4 different id bores,pressure
ability of 1000+ psi, typical “on-column” loadings of 5 to 40 g per 1
litre. You can have both customised volumes & bores.
Unique to us, bores available from 1 mm to 30+ mm id, with flows up to multiple litres/min
IntroPrep™ ~20 to 140 ml. coil id/volume
L-LcMSPrep™ ~20ml to 1mm id bore and ~110 ml/2.1mm id bore, both S/S coils
QuikPrep™ up to ~750 ml, price depending number coils, coil 1d / volume
LabPrep™ up to ~2000ml, price depending number coils, coil 1d / volume
ProcessPrep™ any volume, mutually agreed bore or coil material, 3 to 100’s litres.
ILPrep™ any volume, high pressure Ionic Liquids unit for chromatograhy and extraction.
DualFlow™ any volume for chromatograhy and extraction. Existing usrs can upgrade.
Model Type / Volumes Hydrodynamic Counter-Current Chromatography (CCC / HSCCC / HPCCC / HPL-LC™)
Do you face a challenge with micro,
laboratory or process scale of solid-liquid chromatography / extraction
or sample preparation? Need more than SPE, Flash, HPLC or HPLC-MS, SFC
or SFC-MS, SFE can offer? Contact us now to discuss your hydrodynamic
and / or hydrostatic L-LC / CCC / CPC or Ionic Liquid needs.
Is your challenge on-column adsorption or on-column degradation? Are
your laboratory / process SPE, Flash Chromatography / HPLC / SFC / SFE
phase costs / solvent costs too high? Do you have unexplained loss of
bioactivity, be that beneficial or cyto-toxicity? Need to obtain all
compounds, from infinity polar / non-polar in one run? Do you wish to
prepare Active Product Ingredients (API’s), proteins / peptides /
enzymes / chirals / macromolecules such as engine oil additives /
polysaccharides / tannins / humic acids or even as yet totally unknown
targets / backbone structures?
WE HAVE COMMERCIAL EXPERIENCE OF ALL OF ABOVE (unpublished as carried out
confidentially for clients).
Please Note: we are independent commercial companies, and are not like
several of our competitors, owned/part owned by academic establishments.
We have solved all above application problems for clients with Quattro
or Partitron Liquid-Liquid Chromatography / Extraction solutions unique
to us. Our just released modular, quieter, Quattro Mk 8, High
Performance Liquid-Liquid Chromatography™ / Extraction™ (HPL-LC™/
HPL-LE™) and Partitron HPCPC™ Mk 2 can both work at over 1000 psi,
rather 105 psi of historic HSCCC or HPCCC competitors, and function at
scales from micro gram right up to your process needs limit. Contact us
to discuss your needs.
Click on either thumbnail of the
Quattro CCC (above) or one of the two
Partitron HPCPC brochures (below) to
read full brochure content.
Novel & New: Sun rotors can be custom made in Stainless Steel or Titanium (for proteins etc). Instruments
can have, 1 or 2 different id cell (chamber) bores, with pressure
abilities of 1000+ psi, with typically “on-column” loadings of 5 to 40
g per 1 litre. HPCPC is ideal for MAB’s, proteins, peptides &
enzymes, other organic and inorganic extractions or chromatography
Unique to us, custom design options for Quattro HPCPC™. You choose cell
/ chamber bores, available 6 mm to 22+ mm id, chose different chamber
id’s, numbers, and volumes on same instrument by mutual agreement.
Nobody else offers you the same custom design flexibility.
IntroPrep HPCPC™ Laboratory Instruments. ~100 ml to 1,000ml, Stainless Steel or Titanium rotor,
6 mm bore cell / chambers, other id’s by mutual agreement
QuikPrep HPCPC™ Laboratory or Pilot Plant Instruments.
~100 ml to 4,500ml, Stainless Steel or Titanium rotor. Options of 6 mm
or 10 mm bore cell / chambers, other id’s by mutual agreement
ProcessPrep HPCPC™ Process ATEX Design.
Stainless Steel or Titanium rotor, with 6,000 to 18,000+ ml modules.
Any number 6 litre modules can be used in parallel or for Simulated
Moving Bed (SMB).
Partitron HPCPC™ Process ATEX Design.
Titanium rotor only, with 25,000+ ml modules. Parallel use multi-25
litre rotor units allows up-to any volume, even to 100’s litres. 22 mm
Partitron HPCPC & Quattro HPCPC both
suitable, standard solvents, Ionic Liquid or Liquid CO2 for Pilot or
Process Plant SFE, SFC, Liquid-Liquid Extraction and Chromatography.
Model Type / Volumes Hydrostatic CCC, Droplet Centrifugal Partition Chromatography (CPC / HPCPC )
collaboration with Couturier, brings you both talent and stability.
Both Company groups have been trading as same family owned Companies
for approximately 30 years.
Since 1983 AECS has been doing contract design research for third party
instrument companies. Projects included the design of moving belt
HPLC-MS, HPLC-FID and HPLC-MPD detectors; evaporative light scatter
detectors; the world's first peltier HPLC column air ovens / chillers,
etc. AECS has also helped an USA based HPLC Column Company create
completely new HPLC column / phase product lines. AECS has built
numerous prototype instruments for Blue-Chip International Companies.
AECS built our first Quattro CCC™ in the early 1990's, when Smith Kline
Beecham were not prepared to purchase the then existing CCC / CPC
instrumentation, and placed an open-design Purchase Order with AECS for
what became the Quattro CCC™ Mk I. They like many others, before and
since, trusted AECS's design expertise,
and contracted AECS to build an improved design with regard to both
safety and performance. Since then we have designed and built numerous
custom Quattro HPL-LC™ for many clients.
Our combined Groups have a million plus Euro turnover. We have in-house
both design offices and extremely sophisticated, state of art, large
scale, specialist multi axis CNC machining (see slide show)(see in
house multi-axis machining of large scale titanium rotor), plus a
diversified product and customer base.
We offer our client’s proven, but ever evolving, commercially relevant
countercurrent chromatography units. We have over 18 years of worldwide
counter-current chromatography commercial trading experience. We sell
CCC / HSCCC / HPCCC / HPL-LC™ / CPC / HPCPC from microgram, that are
scalable to your process needs. Our very large process scale HPCPC,
uniquely has a titanium rotor unit. It is modular, with any number of
25 litre modules available all in one cohesive instrument, the
Commercial & Scientific Advantages Compared to Competitors
Scale-up Advantages Compared to Competitors
Modular design, and the use of interchangeable components is common in aerospace, car,
electronics etc industry. But only AECS-QuikPrep and Couturier have employed this concept
to countercurrent chromatography. We did to ensure success in scale-up..
What is Counter Current Chromatography / Centrifugal Partition Chromatography /
High Performance Liquid – Liquid Chromatography™ / High Performance Liquid –
Liquid Extraction™ ?
visiting our NEW DEMONSTRATION LABORATORY near Newquay Airport, only 1
hour flight from London Gatwick, and with good connections to many
National & International Airports.
Please consider requesting Dr Leslie Brown visiting you to discuss your larger scale process needs.
If you are interested in collaborative
research, please suggest a topic.We are
particularly interested in high pressure SFE
/ SFC / SFC-MS / L-LC direct to MS
applications, but have a general interest in
many subjects from trace to process quantities.
Stainless Steel coiled 18-litre Quattro ProcessPrep™ HPL-LC™ unit start
from LESS THAN HALF PRICE of low backpressure PFA coiled (only
~105psi), 18 litre UK competitors’ process HPCCC units?
Being modular the process Quattro HPL-LC™ (starting from 3 litres),
allow you to start your process chromatography or extraction with at low-cost with one unit. Add capacity only as required. Perfect for Simulated Moving Bed use.
Like to have different bobbins sets with different bores / volumes for
different requirements or SMB? You can with Quattro Process HPL-LC™,
but not with competitors.
New Quattro HPL-LC™ Mk 8
typical sample preparation times are only 20 to 60+ minutes. Solvent
usage for same mass injected can be up to 90% less than Flash or HPLC, and also 40 to 90% often less than many CCC / HSCCC / HPCCC / CPC / HPCPC, from HSCCC / HPCCC competitors.
Our unique modular design means that you can have an instrument custom made to your needs and budget.
Do you need Counter-Current Chromatography Process Scale-up?
Please read below. If not skip to next box.
Partitron & Quattro
HPCPC™ ATEX approved, Intrinsically Safe units are worldwide the only
HPCPC (High Performance Centrifugal Partition Chromatography) with TITANIUM ROTOR OPTIONS and STOPPED USE OF ANY LEAK-PRONE PTFE SEALS, so suitable steam cleaning.
Many of our competitors only have units where their parent academic
University / Research Institute shareholders obtained grants for
“one-off” builds. We have supplied industrial process units for several
The modular Process Compatible, ATEX specification, Quattro HPCPC start
at 6 litre modules & ATEX Partitron HPCPC™ range begins at 25 litre
units. Scale-up “in-parallel” by use of multiple 6 or 25 litre units
easily available. Add capacity with additional modular 6 or 25 litre
rotors as & when required.
Or consider our Process HPCPC for Simulated Moving Bed use,
standard solvent or IONIC LIQUID solvents or Liquid CO2 use for
CHROMATOGRAPHY OR EFFICIENT EXTRACTION.
Do you need Centrifugal Partition Chromatography Process Scale-up?
Consider using Dr Leslie Brown's lifetime of chromatography experience to help you?
Dr Les Brown has extensive commercial
experience in laboratory and process HPCCC, HPL-LC™, plus CPC and
HPCPC. He has scale-up experience from laboratory to the process
Partitron HPCPC™ etc., which will stand you in a highly favoured
position, when you move to potentially multiple tonnes per annum GMP
production. The Quattro CCC™ / HPL-LC™ / CPC™ & HPCPC™ are
respected quality products, with clients throughout the World. Our
unique high backpressure capability will facilitate HPLC-MS, SFE, SFC,
SFC-MS, Ionic Liquid research / process production by either efficient
extraction or chromatography in laboratory + process procedures.
Centrifugal Partition (Hydrostatic CCC) Chromatography Quattro
and Partitron Hydrostatic CCC (CPC) models (historically called high
performance centrifugal partition chromatography) offer the options of
6 or 10 mm cell bores in laboratory units, plus 10, 15 or 22 mm cell
bores for the 5 to 18+ litre capacity Quattro HPCPC™, or 22m for
Partitron HPCPC™. These instruments can be utilised with standard and
slow-settling biphasic solvents. Examples of latter: aqueous / aqueous
(PEG or Dextran) mixes, and butanol based mixes. Typical applications
would be MAB’s, protein, peptide, and enzyme production. To facilitate
the above, we offer PTFE or TITANIUM rotors, as competitors’ stainless
steel rotors could be unsuitable for certain target, biologically etc
active compounds. Custom CPC rotor chamber id’s and volumes, and
Counter-Current (Hydrodynamic CCC) Chromatography
All Quattro Hydrodynamic CCC models
share the same planet & sun radii, beta values, speed / “G” Force
options. We will now guarantee in writing the Quattro scale-up for any
given bore, by increase in coil length / volume. In the vast
majority of cases predictable scale-up occurs for different bore id’s
as well. But rare exceptions occur even when you maintain all key
design parameters. Our almost 20 years of experience suggests the more
key design parameters you change, more scale-up failures occur,
irrespective of constant “G” force. We challenge our HPCCC competitors
to dispute this statement. There inability to do so proves the
conceptual inferiority of their products, as they foolishly vary all
key design parameters, except “G” force.
Uniquely to us, we recognise the importance of proving scale-up with
laboratory instruments. We give you lower-cost laboratory scale,
Quattro LabPrep™ / ProcessPrep™ units that can be used for full process
scale testing at bores up to 30+ mm. No competitor gives you lab-scale
units to test process-scale bore id’s etc.
Do you believe competitors’ bias suggestions based on limited published
topics? Their instrument designs, ranging from mini-units with
cotton-reel sized bobbins rotating at ~2000 rpm & id of 0.8mm, are
suggested to behave routine chromatographically the same as maxi-units
which you could stand inside rotating at ~800 rpm and ~10 mm id, simply because “G” Force is the same? We do not believe their bias suggestions. We do believe HEMWat solvents have only limited applications, but they misleadingly emphasise HEMWat.They say 90+% their preparations use HEMWat.
We say HEMWat biphasic solvents totally useless for most proteins, many
peptides, many enzymes, very many natural products / synthetic mixtures.
AECS & ETS Personnel Pics
From the left
Dr Les Brown, MD of AECS-QuikPrep Ltd
Pierre-Henri Garret, MD of Couturier
We are seeking additional specialist EXCLUSIVE DISTRIBUTORS
OUR NEWS BOX AECS-QuikPrep
Ltd has begun a three way collaboration with University of Belfast and
UCL, London for EPSRC funded Grant Research into Unique Applications of
IONIC LIQUID use in Quattro CCC and CPC.
Quattro HPCPC™ suitable for IONIC LIQUIDS, and LIQUID-CO2 applications such as possibly SFE, SFC, just released.
New Demonstration Only 6 litre ATEX, Partitron HPCPC™ Mk 2 available to view.
New Demonstration 4.5 litre non-ATEX, Quattro PilotPrep Mk 9
Available for demonstrations. Suitable for large scale preparations in
Highly Specialist Titanium Multi-Dimensional
Machining of 25 Litre Rotor which was designed by,
and is machined by ourselves
PLEASE SCROLL DOWN TO VIEW FULL INFORMATION AND SITE INDEX
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