Quattro LabPrep CCC & CPC units: 250 to 2000ml total instrument volume. Option multiple volumes per instrument from 30ml. Price range £26,900 to £79,500.
Scaling-Up your application?
Scale-up to multiple tonnes per annum possible.
Pilot & Process Scale CPC Prices
£123,000 Quattro PilotPrep CPC 4.8 litres.
£170,000 Quattro ProcessPrep CPC 12 litres. MEDICINAL CANNABINOID INDUSTRY USERS ETC., SPECIAL OFFER UNTIL MARCH 2020 :
£250,000 for 2 x 12 litres (24 litres) & £360,000 for 3 x 12 litres (36 litres). After 1st March 2020 will be £280,000 for 2 x 12 litres & £420,000 for 3 x 12 litres
The above pricing for scale-up, could include customised Ancillary
Instrumentation to match your needs and budget. We have considerable
specification flexibility, and always match our quotes to give you the
best value, to as closely match your needs as possible, for your budget.
AECS-QuikPrep is undoubtedly the World Leaders in Counter-Current,
Centrifugal Partition, Liquid-Liquid, Ionic Liquid Chromatography /
We manufacture both Hydrodynamic CCC
(Planetary CCC, HSCCC, HPCCC, HPL-LC™) and Hydrostatic CCC (Droplet
Centrifugal Partition Chromatography, CPC, HPCPC) at scales from 30 ml
to 100+ litres. We have units in both research laboratories and process
manufacture units throughout the World. We collaborate with Research
Institutes / Universities, for both standard solvents and IONIC LIQUID
BIPHASIC CCC/CPC EXTRACTION & CHROMATOGRAPHY RESEARCH PROGRAMME
We can custom build both CCC & CPC unit’s specific for your
requirements because of our unique modular construction. Options of
different CCC bore or CPC cell / chamber sizes, different volumes on
the same instrument. We can custom design to accommodate your specific
needs, within your budget. Other competitors cannot match our design
and build flexibility. Just ask them and us to custom build to your
specific needs and budget. We will custom build to match your
Unique 2D Spiral CCC for UK clientUnique Dual Flow for USA client AECS Exhibiting at CCC 2014
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COUNTER CURRENT CHROMATOGRAPHY & CENTRIFUGAL PARTITION CHROMATOGRAPHY
AECS-QUIKPREP LTD uniquely brings you laboratory and process
chromatography and extraction at scales from milligrams to tonnes per annum
• Save ~50-90% process chromatography/extraction, solvent/column costs
• Ideal HPLC-MS pre-prep; no column induced degradation or adsorption
• Uniquely allows infinitely polar to infinitely non-polar prep in one run
• Contract laboratory and process method development services available
• Easily scale-up from micro-gram to your tonne plus process scale
• Orthogonal selectivity options compared to HPLC / Flash / SFC
• No solubility problems; massive range of solvents available
• IL / SFC / SFC-MS / MS / MS-MS / HPLC / HPLC-MS compatible
• High mass loading (typically 5 to 40 g per 1000ml capacity)
• Inject up to 10+ % coil volume without excessive band spreading
• High pressure (1000psi+) + high “G” (80-150)(250)(350+) options
• Only manufacturers of both hydrodynamic & hydrostatic CCC
• New dedicated IONIC LIQUID CHROMATOGRAPHY/EXTRACTION CCC/CPC
• New MULTI-COIL, 2D & 3D DUAL-FLOW CCC/CPC extraction options,
Quattro HPL-LC™ / HTPrep™ Video (2 bobbins, 4 coils / 3 coil id’s). Door safety
mechanism disabled for this demonstration video.Set spin speeds are very constant. The video
judder is caused by camera/internet
technology. Instrument video above is a standard, multi-layer, 3D planetary CCC
MEDICINAL CANNABINOID PROCESS PURIFICATIONS ARE OUR SPECIALITY!!!
LabPrep™ Total volume options from 250ml to 2000ml. Options of 2, 3 or 4 coils per instrument. You can choose multiple volume of coils to suit your specific needs. Coils of same id can be utilised in series, to gain resolution or additional mass injected. Coil id options: 1 mm id, 2 mm id, 4.6 mm id. Coil material options: PTFE, PFA, PEEK, Stainless Steel.
LabPrep™ up to ~2000ml, price depending number coils, coil 1d / volume
PilotPrep™ 4.8 litres CCC. Can work in standard laboratory.
Images of Counter Current Chromatograph and Centrifugal Partition Chromatograph, showing CCC & CPC plus ancillaries at AECS-QuikPrep Ltd Demonstration Laboratory
Note: The Quattro PilotPrep CPC shown can process kilos per day, but still be utilised in a standard laboratory.
Model Type / Volumes Hydrodynamic Counter-Current Chromatography (CCC / HSCCC / HPCCC / HPL-LC™)
Commercial & Scientific Advantages Compared to Competitors
The AECS brings you both talent and stability.
AECS has been trading as same family owned Companies
for approximately 30 years.
Since 1983 AECS has been doing contract design research for third party
instrument companies. Projects included the design of moving belt
HPLC-MS, HPLC-FID and HPLC-MPD detectors; evaporative light scatter
detectors; the world's first peltier HPLC column air ovens / chillers,
etc. AECS has also helped an USA based HPLC Column Company create
completely new HPLC column / phase product lines. AECS has built
numerous prototype instruments for Blue-Chip International Companies.
AECS built our first Quattro CCC™ in the early 1990's, when Smith Kline
Beecham were not prepared to purchase the then existing CCC / CPC
instrumentation, and placed an open-design Purchase Order with AECS for
what became the Quattro CCC™ Mk I. They like many others, before and
since, trusted AECS's design expertise,
and contracted AECS to build an improved design with regard to both
safety and performance. Since then we have designed and built numerous
custom Quattro HPL-LC™ for many clients.
We offer our client’s proven, but ever evolving, commercially relevant
countercurrent chromatography units. We have over 26 years of worldwide
counter-current chromatography commercial trading experience. We sell
CCC / HSCCC / HPCCC / HPL-LC™ / CPC / HPCPC from microgram, that are
scalable to your process needs.
Click on thumbnail of the
Quattro CCC (above) brochures to
read full brochure content.
Novel & New: Sun rotors can be custom made in Stainless Steel or Titanium (for proteins etc).
can have, 1 or 2 different id cell (chamber) bores, with pressure
abilities of 1000+ psi, with typically “on-column” loadings of 5 to 40
g per 1 litre. HPCPC is ideal for MAB’s, proteins, peptides &
enzymes, other organic and inorganic extractions or chromatography
AECS’s unique multi-block CPC rotor design offers specification options and tolerance to client induced mistakes causing CPC rotor blockage etc., which means significantly less downtime than any competitor. All Quattro CPC built to ISO 9001.
LabPrep CPC™ Laboratory
~250 ml to 2000 ml, Stainless Steel rotor.
PilotPrep™ 4.8 litres. May be used in standard laboratories worldwide.
ProcessPrep™ any volume up to 100's of litres. Must be used in Intrinsically Safe \ Explosion Proof ATEX 1, in Europe
or C1-D1 in the USA or Canada.
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Model Type / Volumes Hydrostatic CCC, Droplet Centrifugal Partition Chromatography (CPC / HPCPC )
Centrifugal Partition Chromatography Medicinal Cannabinoid Chromatographs performed on our clients’ samples…...
Scale-up Advantages Compared to Competitors
Modular design, and the use of interchangeable components is common in aerospace, car,
electronics etc industry. But only AECS-QuikPrep has employed this concept
to countercurrent chromatography. We did to ensure success in scale-up..
visiting our NEW DEMONSTRATION LABORATORY near Newquay Airport, only 1
hour flight from London Gatwick, and with good connections to many
National & International Airports.
Please consider requesting Dr Leslie Brown visiting you to discuss your larger scale process needs.
If you are interested in collaborative
research, please suggest a topic.We are
particularly interested in high pressure SFE
/ SFC / SFC-MS / L-LC direct to MS
applications, but have a general interest in
many subjects from trace to process quantities.
IMAGES OF QUATTRO CENTRIFUGAL PARTITION CHROMATOGRAPHS FOR PROCESS CHROMATOGRAPHY OF MEDICINAL CANNABINOIDS ETC
First Delivery Equipment PilotPrep USAEarly Stage Install PilotPrep USA. Click thumbnail to expand
Installation with on-site training in your laboratory for one week included in Retail Price for Quattro PiliotPrep™ and ProcessPrep™. Price includes time and airfares, client provides accommodation and car hire.
The modular Process Compatible, ATEX 1 specification in Europe, C1-D1 specification in USA and Canada, QuattroProcessPrepHPCPC start
at 12 litres and go to 100's of litres.
Or consider our Process HPCPC for Simulated Moving Bed use,
standard solvent or IONIC LIQUID solvents or Liquid CO2 use for
CHROMATOGRAPHY OR EFFICIENT EXTRACTION.
Do you need Centrifugal Partition Chromatography Process Scale-up?
Consider using Dr Leslie Brown's lifetime of chromatography experience to help you?
Dr Les Brown has extensive commercial
experience in laboratory and process HPCCC, HPL-LC™, plus CPC and
HPCPC. He has scale-up experience from laboratory to the process
Partitron HPCPC™ etc., which will stand you in a highly favoured
position, when you move to potentially multiple tonnes per annum GMP
production. The Quattro CCC™ / HPL-LC™ / CPC™ & HPCPC™ are
respected quality products, with clients throughout the World. Our
unique high backpressure capability will facilitate HPLC-MS, SFE, SFC,
SFC-MS, Ionic Liquid research / process production by either efficient
extraction or chromatography in laboratory + process procedures.
Counter-Current (Hydrodynamic CCC) Chromatography
All Quattro Hydrodynamic CCC models
share the same planet & sun radii, beta values, speed / “G” Force
options. We will now guarantee in writing the Quattro scale-up for any
given bore, by increase in coil length / volume. In the vast
majority of cases predictable scale-up occurs for different bore id’s
as well. But rare exceptions occur even when you maintain all key
design parameters. Our almost 20 years of experience suggests the more
key design parameters you change, more scale-up failures occur,
irrespective of constant “G” force. We challenge our HPCCC competitors
to dispute this statement. There inability to do so proves the
conceptual inferiority of their products, as they foolishly vary all
key design parameters, except “G” force.
Uniquely to us, we recognise the importance of proving scale-up with
laboratory instruments. We give you lower-cost laboratory scale,
Quattro LabPrep™ / ProcessPrep™ units that can be used for full process
scale testing at bores up to 30+ mm. No competitor gives you lab-scale
units to test process-scale bore id’s etc.
Do you believe competitors’ bias suggestions based on limited published
topics? Their instrument designs, ranging from mini-units with
cotton-reel sized bobbins rotating at ~2000 rpm & id of 0.8mm, are
suggested to behave routine chromatographically the same as maxi-units
which you could stand inside rotating at ~800 rpm and ~10 mm id, simply because “G” Force is the same? We do not believe their bias suggestions. We do believe HEMWat solvents have only limited applications, but they misleadingly emphasise HEMWat.They say 90+% their preparations use HEMWat.
We say HEMWat biphasic solvents totally useless for most proteins, many
peptides, many enzymes, very many natural products / synthetic mixtures.
Dr Leslie Brown, MD of AECS-QuikPrep Ltd
Quattro Process CPC are World Leaders in Purification of MEDICINAL CANNABINOIDS
OUR NEWS BOX 1) AECS-QUIKPREP LTD continues to co-research Ionic Liquid – CCC and CPC with Queens University Belfast, with novel process instruments due shortly.
2) Multiple Quattro Process CPC installed for MEDICINAL CANNABIOID PURIFICATIONS, both Quattro PilotPrep CPC and multiple installations of Quattro ProcessPrep CPC
3) Most Quattro ProcessPrep CPC installations for MEDICINAL CANNABINOID PROCESSES. MARIJUANA EXTRACTS (only to licensed THC producers) and HEMP PROCESSORS (for CBD and minor cannabinoid purification, and THC removal from broad spectrum Hemp Extracts).
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