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GUIDE PRICING TO ASSIST YOUR BUDGETING.
Quattro LabPrep CCC & CPC units: 250 to 2000ml total instrument volume. Option multiple volumes per instrument from 30ml. Price range £26,900 to £79,500.
Scaling-Up your application?
Scale-up to multiple tonnes per annum possible.
Pilot & Process Scale CPC Prices
£123,000 Quattro PilotPrep CPC 4.8 litres.
£170,000 Quattro ProcessPrep CPC 12 litres.
MEDICINAL CANNABINOID INDUSTRY USERS ETC., SPECIAL OFFER UNTIL MARCH 2020 :
£250,000 for 2 x 12 litres (24 litres) & £360,000 for 3 x 12 litres (36 litres). After 1st March 2020 will be £280,000 for 2 x 12 litres & £420,000 for 3 x 12 litres
The above pricing for scale-up, could include customised Ancillary
Instrumentation to match your needs and budget. We have considerable
specification flexibility, and always match our quotes to give you the
best value, to as closely match your needs as possible, for your budget.
We manufacture both Hydrodynamic CCC (Planetary CCC, HSCCC, HPCCC, HPL-LC™) and Hydrostatic CCC (Droplet Centrifugal Partition Chromatography, CPC, HPCPC) at scales from 30 ml to 100+ litres. We have units in both research laboratories and process manufacture units throughout the World. We collaborate with Research Institutes / Universities, for both standard solvents and IONIC LIQUID BIPHASIC CCC/CPC EXTRACTION & CHROMATOGRAPHY RESEARCH PROGRAMME
We can custom build both CCC & CPC unit’s specific for your requirements because of our unique modular construction. Options of different CCC bore or CPC cell / chamber sizes, different volumes on the same instrument. We can custom design to accommodate your specific needs, within your budget. Other competitors cannot match our design and build flexibility. Just ask them and us to custom build to your specific needs and budget. We will custom build to match your requirements.
Unique 2D Spiral CCC for UK client Unique Dual Flow for USA client AECS Exhibiting at CCC 2014
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chromatography and extraction at scales from milligrams to tonnes per annum
• Ideal HPLC-MS pre-prep; no column induced degradation or adsorption
• Uniquely allows infinitely polar to infinitely non-polar prep in one run
• Contract laboratory and process method development services available
• Easily scale-up from micro-gram to your tonne plus process scale
• Orthogonal selectivity options compared to HPLC / Flash / SFC
• No solubility problems; massive range of solvents available
• IL / SFC / SFC-MS / MS / MS-MS / HPLC / HPLC-MS compatible
• High mass loading (typically 5 to 40 g per 1000ml capacity)
• Inject up to 10+ % coil volume without excessive band spreading
• High pressure (1000psi+) + high “G” (80-150)(250)(350+) options
• Only manufacturers of both hydrodynamic & hydrostatic CCC
• New dedicated IONIC LIQUID CHROMATOGRAPHY/EXTRACTION CCC/CPC
• New MULTI-COIL, 2D & 3D DUAL-FLOW CCC/CPC extraction options,
Quattro HPL-LC™ / HTPrep™ Video
(2 bobbins, 4 coils / 3 coil id’s). Door safety mechanism disabled for this demonstration video. Set spin speeds are very constant. The video judder is caused by camera/internet technology. Instrument video above is a standard, multi-layer, 3D planetary CCC
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Click this link to read our review of Ionic Liquid-Counter Current Chromotography / Centrifugal Partition Chromotograhy research in Topics in Current Chemistry. |
MEDICINAL CANNABINOID PROCESS PURIFICATIONS ARE OUR SPECIALITY!!!
LabPrep™ Total volume options from 250ml to 2000ml. Options of 2, 3 or 4 coils per instrument. You can choose multiple volume of coils to suit your specific needs. Coils of same id can be utilised in series, to gain resolution or additional mass injected. Coil id options: 1 mm id, 2 mm id, 4.6 mm id. Coil material options: PTFE, PFA, PEEK, Stainless Steel.
LabPrep™ up to ~2000ml, price depending number coils, coil 1d / volume
PilotPrep™ 4.8 litres CCC. Can work in standard laboratory.
Images of Counter Current Chromatograph and Centrifugal Partition Chromatograph, showing CCC & CPC plus ancillaries at AECS-QuikPrep Ltd Demonstration Laboratory
Note: The Quattro PilotPrep CPC shown can process kilos per day, but still be utilised in a standard laboratory.
The AECS brings you both talent and stability. AECS has been trading as same family owned Companies for approximately 30 years.
Since 1983 AECS has been doing contract design research for third party instrument companies. Projects included the design of moving belt HPLC-MS, HPLC-FID and HPLC-MPD detectors; evaporative light scatter detectors; the world's first peltier HPLC column air ovens / chillers, etc. AECS has also helped an USA based HPLC Column Company create completely new HPLC column / phase product lines. AECS has built numerous prototype instruments for Blue-Chip International Companies.
AECS built our first Quattro CCC™ in the early 1990's, when Smith Kline Beecham were not prepared to purchase the then existing CCC / CPC instrumentation, and placed an open-design Purchase Order with AECS for what became the Quattro CCC™ Mk I. They like many others, before and since, trusted AECS's design expertise, and contracted AECS to build an improved design with regard to both safety and performance. Since then we have designed and built numerous custom Quattro HPL-LC™ for many clients.
We offer our client’s proven, but ever evolving, commercially relevant countercurrent chromatography units. We have over 26 years of worldwide counter-current chromatography commercial trading experience. We sell CCC / HSCCC / HPCCC / HPL-LC™ / CPC / HPCPC from microgram, that are scalable to your process needs.
Click on thumbnail of the Quattro CCC (above) brochures to read full brochure content.
Novel & New: Sun rotors can be custom made in Stainless Steel or Titanium (for proteins etc).
Instruments
can have, 1 or 2 different id cell (chamber) bores, with pressure
abilities of 1000+ psi, with typically “on-column” loadings of 5 to 40
g per 1 litre. HPCPC is ideal for MAB’s, proteins, peptides &
enzymes, other organic and inorganic extractions or chromatography
purifications.
AECS’s unique multi-block CPC rotor design offers specification options and tolerance to client induced mistakes causing CPC rotor blockage etc., which means significantly less downtime than any competitor. All Quattro CPC built to ISO 9001.
LabPrep CPC™ Laboratory
~250 ml to 2000 ml, Stainless Steel rotor.
PilotPrep™ 4.8 litres. May be used in standard laboratories worldwide.
ProcessPrep™ any volume up to 100's of litres. Must be used in Intrinsically Safe \ Explosion Proof ATEX 1, in Europe
or C1-D1 in the USA or Canada.
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Centrifugal Partition Chromatography Medicinal Cannabinoid Chromatographs performed on our clients’ samples…...
Modular design, and the use of interchangeable components is common in aerospace, car, electronics etc industry. But only AECS-QuikPrep has employed this concept to countercurrent chromatography. We did to ensure success in scale-up..
Please consider requesting Dr Leslie Brown visiting you to discuss your larger scale process needs.
IMAGES OF QUATTRO CENTRIFUGAL PARTITION CHROMATOGRAPHS FOR PROCESS CHROMATOGRAPHY OF MEDICINAL CANNABINOIDS ETC
First Delivery Equipment PilotPrep USA Early Stage Install PilotPrep USA.
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Installation with on-site training in your laboratory for one week included in Retail Price for Quattro PiliotPrep™ and ProcessPrep™. Price includes time and airfares, client provides accommodation and car hire.
The modular Process Compatible, ATEX 1 specification in Europe, C1-D1 specification in USA and Canada, Quattro ProcessPrep HPCPC start at 12 litres and go to 100's of litres.
Or consider our Process HPCPC for Simulated Moving Bed use, standard solvent or IONIC LIQUID solvents or Liquid CO2 use for CHROMATOGRAPHY OR EFFICIENT EXTRACTION.
Dr Les Brown has extensive commercial experience in laboratory and process HPCCC, HPL-LC™, plus CPC and HPCPC. He has scale-up experience from laboratory to the process Partitron HPCPC™ etc., which will stand you in a highly favoured position, when you move to potentially multiple tonnes per annum GMP production. The Quattro CCC™ / HPL-LC™ / CPC™ & HPCPC™ are respected quality products, with clients throughout the World. Our unique high backpressure capability will facilitate HPLC-MS, SFE, SFC, SFC-MS, Ionic Liquid research / process production by either efficient extraction or chromatography in laboratory + process procedures.
All Quattro Hydrodynamic CCC models share the same planet & sun radii, beta values, speed / “G” Force options. We will now guarantee in writing the Quattro scale-up for any given bore, by increase in coil length / volume. In the vast majority of cases predictable scale-up occurs for different bore id’s as well. But rare exceptions occur even when you maintain all key design parameters. Our almost 20 years of experience suggests the more key design parameters you change, more scale-up failures occur, irrespective of constant “G” force. We challenge our HPCCC competitors to dispute this statement. There inability to do so proves the conceptual inferiority of their products, as they foolishly vary all key design parameters, except “G” force.
Uniquely to us, we recognise the importance of proving scale-up with laboratory instruments. We give you lower-cost laboratory scale, Quattro LabPrep™ / ProcessPrep™ units that can be used for full process scale testing at bores up to 30+ mm. No competitor gives you lab-scale units to test process-scale bore id’s etc.
Do you believe competitors’ bias suggestions based on limited published topics? Their instrument designs, ranging from mini-units with cotton-reel sized bobbins rotating at ~2000 rpm & id of 0.8mm, are suggested to behave routine chromatographically the same as maxi-units which you could stand inside rotating at ~800 rpm and ~10 mm id, simply because “G” Force is the same? We do not believe their bias suggestions. We do believe HEMWat solvents have only limited applications, but they misleadingly emphasise HEMWat. They say 90+% their preparations use HEMWat. We say HEMWat biphasic solvents totally useless for most proteins, many peptides, many enzymes, very many natural products / synthetic mixtures.
1) AECS-QUIKPREP LTD continues to co-research Ionic Liquid – CCC and CPC with Queens University Belfast, with novel process instruments due shortly.
2) Multiple Quattro Process CPC installed for MEDICINAL CANNABIOID PURIFICATIONS, both Quattro PilotPrep CPC and multiple installations of Quattro ProcessPrep CPC
3) Most Quattro ProcessPrep CPC installations for MEDICINAL CANNABINOID PROCESSES. MARIJUANA EXTRACTS (only to licensed THC producers) and HEMP PROCESSORS (for CBD and minor cannabinoid purification, and THC removal from broad spectrum Hemp Extracts).
on left for "INTRODUCTION" slide show scientific presentation