Quattro HPL-LC™ / HTPrep™ Video (2 bobbins, 4 coils / 3 coil id’s). Door safety
mechanism disabled for this demonstration video.
Set spin speeds are very constant. The video
judder is caused by camera/internet
Novel & New: Coils can be custom made in PTFE, PFA, PEEK, Stainless Steel (S/S) or Titanium. “G” Force can be Standard (S)(80 to 150G), High (H)(250G+)or unique to us, our new Ultra (U) (350G+), (UPCCC™) / (UPL-LC™).
Your Instrument could have coils with, 1, 2, 3 or even 4 different id bores,pressure ability of 1000+ psi, typical “on-column” loadings of 5 to 40 g per 1 litre. You can have both customised volumes & bores.
Unique to us, bores available from 1 mm to 30+ mm id, with flows up to multiple litres/min
IntroPrep™ ~20 to 140 ml. coil id/volume
L-LcMSPrep™ ~20ml to 1mm id bore and ~110 ml/2.1mm id bore, both S/S coils
QuikPrep™ up to ~750 ml, price depending number coils, coil 1d / volume
LabPrep™ up to ~2000ml, price depending number coils, coil 1d / volume
ProcessPrep™ any volume, mutually agreed bore or coil material, 3 to 100’s litres.
ILPrep™ any volume, high pressure Ionic Liquids unit for chromatograhy and extraction.
DualFlow™ any volume for chromatograhy and extraction. Existing usrs can upgrade.
Model Type / Volumes Hydrodynamic Counter-Current Chromatography (CCC / HSCCC / HPCCC / HPL-LC™)
Click on either thumbnail of the
Quattro CCC (above) or one of the two
Partitron HPCPC brochures (below) to
read full brochure content.
Novel & New: Sun rotors can be custom made in Stainless Steel or Titanium (for proteins etc).
Instruments can have, 1 or 2 different id cell (chamber) bores, with pressure abilities of 1000+ psi, with typically “on-column” loadings of 5 to 40 g per 1 litre. HPCPC is ideal for MAB’s, proteins, peptides & enzymes, other organic and inorganic extractions or chromatography purifications.
Unique to us, custom design options for Quattro HPCPC™. You choose cell / chamber bores, available 6 mm to 22+ mm id, chose different chamber id’s, numbers, and volumes on same instrument by mutual agreement. Nobody else offers you the same custom design flexibility.
IntroPrep HPCPC™ Laboratory Instruments. ~100 ml to 1,000ml, Stainless Steel or Titanium rotor,
6 mm bore cell / chambers, other id’s by mutual agreement
QuikPrep HPCPC™ Laboratory or Pilot Plant Instruments. ~100 ml to 4,500ml, Stainless Steel or Titanium rotor. Options of 6 mm or 10 mm bore cell / chambers, other id’s by mutual agreement
ProcessPrep HPCPC™ Process ATEX Design. Stainless Steel or Titanium rotor, with 6,000 to 18,000+ ml modules. Any number 6 litre modules can be used in series or for Simulated Moving Bed (SMB).
Partitron HPCPC™ Process ATEX Design. Titanium rotor only, with 25,000+ ml modules. Parallel use multi-25 litre rotor units allows up-to any volume, even to 100’s litres. 22 mm bore chambers.
Partitron HPCPC & Quattro HPCPC both suitable, standard solvents, Ionic Liquid or Liquid CO2 for Pilot or Process Plant SFE, SFC, Liquid-Liquid Extraction and Chromatography.
Model Type / Volumes Hydrostatic CCC, Droplet Centrifugal Partition Chromatography (CPC / HPCPC )
Scale-up Advantages Compared to Competitors
Modular design, and the use of interchangeable components is common in aerospace, car,
electronics etc industry. But only AECS-QuikPrep and Couturier have employed this concept
to countercurrent chromatography. We did to ensure success in scale-up..
Please consider visiting our NEW DEMONSTRATION LABORATORY near Newquay Airport, only 1 hour flight from London Gatwick, and with good connections to many National & International Airports.
Please consider requesting Dr Leslie Brown visiting you to discuss your larger scale process needs.
If you are interested in collaborative
research, please suggest a topic.We are
particularly interested in high pressure SFE
/ SFC / SFC-MS / L-LC direct to MS
applications, but have a general interest in
many subjects from trace to process quantities.
High backpressure, Stainless Steel coiled 18-litre Quattro ProcessPrep™ HPL-LC™ unit start from LESS THAN HALF PRICE of low backpressure PFA coiled (only ~105psi), 18 litre UK competitors’ process HPCCC units? Being modular the process Quattro HPL-LC™ (starting from 3 litres), allow you to start your process chromatography or extraction with at low-cost with one unit. Add capacity only as required. Perfect for Simulated Moving Bed use. Like to have different bobbins sets with different bores / volumes for different requirements or SMB? You can with Quattro Process HPL-LC™, but not with competitors.
New Quattro HPL-LC™ Mk 8 typical sample preparation times are only 20 to 60+ minutes. Solvent usage for same mass injected can be up to 90% less than Flash or HPLC, and also 40 to 90% often less than many CCC / HSCCC / HPCCC / CPC / HPCPC, from HSCCC / HPCCC competitors.
Our unique modular design means that you can have an instrument custom made to your needs and budget.
Do you need Counter-Current Chromatography Process Scale-up?
Please read below. If not skip to next box.
Partitron & Quattro HPCPC™ ATEX approved, Intrinsically Safe units are worldwide the only HPCPC (High Performance Centrifugal Partition Chromatography) with TITANIUM ROTOR OPTIONS and STOPPED USE OF ANY LEAK-PRONE PTFE SEALS, so suitable steam cleaning. Many of our competitors only have units where their parent academic University / Research Institute shareholders obtained grants for “one-off” builds. We have supplied industrial process units for several years.
The modular Process Compatible, ATEX specification, Quattro HPCPC start at 6 litre modules & ATEX Partitron HPCPC™ range begins at 25 litre units. Scale-up “in-parallel” by use of multiple 6 or 25 litre units easily available. Add capacity with additional modular 6 or 25 litre rotors as & when required.
Or consider our Process HPCPC for Simulated Moving Bed use, standard solvent or IONIC LIQUID solvents or Liquid CO2 use for CHROMATOGRAPHY OR EFFICIENT EXTRACTION.
Do you need Centrifugal Partition Chromatography Process Scale-up?
Centrifugal Partition (Hydrostatic CCC) Chromatography Quattro and Partitron Hydrostatic CCC (CPC) models (historically called high performance centrifugal partition chromatography) offer the options of 6 or 10 mm cell bores in laboratory units, plus 10, 15 or 22 mm cell bores for the 5 to 18+ litre capacity Quattro HPCPC™, or 22m for Partitron HPCPC™. These instruments can be utilised with standard and slow-settling biphasic solvents. Examples of latter: aqueous / aqueous (PEG or Dextran) mixes, and butanol based mixes. Typical applications would be MAB’s, protein, peptide, and enzyme production. To facilitate the above, we offer PTFE or TITANIUM rotors, as competitors’ stainless steel rotors could be unsuitable for certain target, biologically etc active compounds. Custom CPC rotor chamber id’s and volumes, and numbers available.
Countercurrent (Hydrodynamic CCC) Chromatography
All Quattro Hydrodynamic CCC models share the same planet & sun radii, beta
values, speed / “G” Force options. We will now guarantee in writing the scale-up for any
given bore, by increase in coil length / volume. In the vast majority of cases predictable
scale-up occurs for different bore id’s as well. But rare exceptions occur even when you
maintain all key design parameters. Our almost 20 years of experience suggests the more key
design parameters you change, more scale-up failures occur, irrespective of constant “G”
force. We challenge anyone to dispute this statement. Occasional scale-up failures that we
experience are no different to occasional scale-up exceptions that occur in Process HPLC /
Flash Chromatography for certain target / matrix / phase combinations
But uniquely to us, we recognise this and give you lower-cost laboratory scale Quattro
LabPrepPlus™ units that can be used for full process scale testing at bores up to 30+ mm. No
competitor gives you lab-scale units to test process-scale bore id’s etc. Do you believe
competitors’ suggestions based on very limited Arizona / HEMWat / GUESS mixture solvent
/ target choices, that their instrument designs, with mini-units ranging from cotton reel sized
bobbins rotating at ~2000 rpm, will behave chromatographically the same as maxi-units which
you could stand inside rotating at ~800 rpm, simply because “G” Force is the same at 240G, for
all target / matrix / biphasic solvent systems? No? Nor do we. We also believe HEMWat has
limited applications, excepting restricted polarity pharmaceuticals, they misleading show. They
say 90+% their preparations use HEMWat. We say HEMWat useless for most proteins,
many peptides, many enzymes, very many natural products / synthetic mixtures.
Our genuine, experimentation proven knowledge is based on our almost 20 years of CCC /
HSCCC / HPCCC / CPC / HPCPC / HPL-LC experience. Please ask competitors, to back their
potentially misleading claims by guaranteeing to you their scale-up for all targets /
matrices / biphasic systems in writing. What happens when you buy a competitors’
£400000+ / 18+ litre / 10 mm id bore process unit and scale up fails? Would it be cost-effective
to optimise a method on such an expensive unit?. Contact us at
Your 1st Choice for Preparative and Process Chromatography / Extraction
Click on picture
on left for
Click on picture on
left for "Quattro
YOUR SAFETY IS OUR MAJOR CONCERN. Now
you have seen the video, we imagine you
understand why, given our concern for your
safety, we were first to use total containment 10
mm thick casework, with massively strong hinges
and door inter-lock bar, with options of bench
lock-down, automated switch off etc. Plus why
we were first, and to date, only manufacturer
with one-pass airflow in rotor chamber.
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